Silent mutation Totally Explained

Everything about Silent Mutation totally explained

Silent mutations are DNA mutations that don't result in a change to the amino acid sequence of a protein. They may occur in a non-coding region (outside of a gene or within an intron), or they may occur within an exon in a manner that doesn't alter the final amino acid sequence. The phrase silent mutation is often used interchangeably with the phrase synonymous mutation; however, synonymous mutations are a subcategory of the former, occurring only within exons. Because silent mutations don't alter protein function they're often treated as though they're evolutionarily neutral. However, many organisms are known to exhibit codon usage biases, suggesting that there's selection for the use of particular codons due to translational stability. Silent mutations may also affect splicing, or transcriptional control.
In molecular cloning experiments, it can be useful to introduce silent mutations into a gene of interest in order to create or remove recognition sites for restriction enzymes. An online tool that can analyse a sequence of interest for possible mutations to create restriction sites is given in the External Links section.
Recent results suggest that silent mutations can have an effect on subsequent protein structure and activity,.

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